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OBJECTIVE:To compare the clinical efficacy and safety of amiodarone and propafenone in the treatment of chron-ic atrial fibrillation cardioversion. METHODS:60 patients with chronic atrial fibrillation cardioversion were randomly divided into propafenone group and amiodarone group. All patients were given conventional treatment,including treating primary disease,con-trolling symptoms,orally giving aspirin,intravenous infusion of GIK,monitoring heart rate,QT interval,P-R interval,QRS time,serum potassium and serum magnesium,etc. On this basis,propafenone group was orally given propafenone 450 mg for con-tinuous 3 months,3 times a day,and then the dose was decreased to 300 mg to maintain the sinus rhythm;amiodarone group was orally given amiodarone 200 mg for continuous 7 d a month,twice a day,and then the dose was decreased to 200 mg or 100 mg to maintain the sinus rhythm. The clinic data in 2 groups was observed,including clinical efficacy,simple drug cardioversion,elec-trical cardioversion,electrical cardioversion power,hospitalization time and incidence of adverse reactions,and the recurrence rate in 48 months was followed up. RESULTS:There were no significant differences in the clinical efficacy,simple drug cardiover-sion,electrical cardioversion,electrical cardioversion power,hospitalization time,incidence of adverse reactions and recurrence rate between 2 groups(P>0.05). CONCLUSIONS:Based on the conventinal treatment,amiodarone and propafenone have similar clinical efficacy and safety in the treatment of chronic atrial fibrillation cardioversion,and both of them can be used as the conven-tional drugs for treating chronic atrial fibrillation cardioversion.
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To prepare oroxylum indicum ( OLI) buccal tablets. Methods:The extract of oroxylum indicum as the main component, the buccal tablets were prepared using a wet granulation compression method. According to the results of single factor ex-periments, an orthogonal design was used to select the optimal formula based on the appearance, taste, disintegration time and friabili-ty. The average weight variation and average disintegration time were tested to evaluate the quality of three batches of the buccal tablets with the optimized formula. Results:The optimal formula was composed of 50%mannitol, 5%sucrose-stevioside (100∶1), 5% pep-permint oil and 35%PVP-K30-85% ethanol (6∶10). For the three batches of the buccal tablets with the optimized formula, the aver-age weight variation was (1. 83 ± 0. 29) % and the average disintegration time was(14. 7 ± 0. 6) min, which met the requirements of quality control on buccal tablets in Chinese pharmacopoeia. Conclusion:The optimal formula and process of OLI buccal tablets show fine reproducibility and stability.
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Objective To study the effects of Xiaofengzhiyang Particles and Levocetirizine on elderly urticaria and effects on the serum levels of IL-2 and IgE.Methods 96 elderly patients were randomly divided into two groups.The patients in study group were prescribed with Xiaofengzhiyang Particles and Levocetirizine.The patients in control group were prescribed with Levocetirizine,two weeks for a course.The curative effect and serum levels of IL-2 and IgE were observed after treatment.Results The complete cure rate of the study group was 69.6％,the control group was 52.5％.There was significant difference between the two groups(P＜0.05).The serum levels of IL-2 and IgE were significantly decreased in study group(all P＜0.01).Conclusion Xiaofengzhiyang Particles combined with Levocetirizine is effective in treating elderly urticaria,and the two drugs together could reduce the serum levels of IL-2 and IgE.
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OBJECTIVE: To explore the effects of piracetam on superoxide dismutase(SOD) activity and malonaldehyde(MDA) content in brain tissues of D-galactose-induced ageing rats.METHODS: 30 SD rats were randomized to one of the 3 groups: blank control group(NS),model group(D-galactose+NS) and piracetam group(D-galactose+piracetam 432 mg?kg-1?d-1).All the rats were put to death at 90 days after medication,and the SOD activity and MDA content in brain tissues were determined.RESULTS: As compared with the blank control,the SOD activity decreased(P
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OBJECTIVE:To investigate the drug quality in rural area during the period of the national rural "two networks" construction.METHODS:A questionnaire investigation on the rate of qualified during 5 years was conducted in which the data of 26 provinces(or cities)which were valid were given a curve fitting analysis.RESULTS:The rate of qualified of chemical drug showed an increasing tendency year by year,so did the Chinese traditional medicine.And the latter's development trend was better than the former.CONCLUSIONS:The eligible proportion of drugs showed an uptrend year by year,and the "two networks" construction in rural areas remarkably enhanced the drug quality in rural area.